| Autor: |
Iu F, Krylov, T L, Kononenkko, P A, Smirnov, R A, Tigranian, N F, Kalita |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Voprosy meditsinskoi khimii. 35(3) |
| ISSN: |
0042-8809 |
| Popis: |
Development of hypoglycemia, a slight decrease in concentration of glucagon in blood as well as increase in activity of malate-and glucose-6-phosphate dehydrogenases in liver cytosol were detected in rats injected subcutaneously with nicotinamide at a dose of 31.25 mg/kg 6 hrs before decapitation. Increase of the single dose up to 125 mg/kg caused hypoglycemia, distinct increase in concentration of insulin and glucagon in blood plasma simultaneously with a pronounced inhibition of the enzymatic activity in liver tissue. Effect of nicotinamide on carbohydrate metabolism appears to have a dissimilar character depending on the drug dose: its small doses accelerated utilization and oxidation of glucose but did not affect the secretion of insulin and glucagon. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
