| Autor: |
T, Børsting, A, Schuller, P, van Dommelen, S N, Stafne, M S, Skeie, A B, Skaare, S, Mørkved, K Å, Salvesen, A K, Stunes, M P, Mosti, M K, Gustafsson, U, Syversen, T N, Fagerhaug |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry. 23(4) |
| ISSN: |
1996-9805 |
| Popis: |
The study aimed to investigate associations between maternal vitamin D status during pregnancy and molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) among children.The study had a longitudinal design using prospectively collected data from 176 mother and child pairs. Mothers were initially recruited in a randomised controlled trial to assess a pregnancy exercise programme. Along with the 7-year follow-up, we invited the children to a dental examination. The exposure variable was maternal serum 25-hydroxyvitamin D in gestational weeks 18-22 and 32-36, categorised as insufficient ( 50 nmol/l) and sufficient (≥ 50 nmol/l). Negative binomial hurdle models were used to analyse potential associations between the exposure variables and MIH or HSPM. The models were adjusted for potential confounders.Among the children (7-9 years old), 32% and 22% had at least one tooth with MIH or HSPM, respectively. A significant association was found between insufficient maternal vitamin D measured in gestational weeks 18-22 and the number of affected teeth among those with MIH at 7-9 years (adjusted RR = 1.82, 95% CI 1.13-2.93).Considering any limitations of the present study, it has been shown that insufficient maternal serum vitamin D at mid-pregnancy was associated with a higher number of affected teeth among the offspring with MIH at 7-9 years of age. Further prospective studies are needed to investigate whether this finding is replicable and to clarify the role of maternal vitamin D status during pregnancy and MIH, as well as HSPM, in children. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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