| Autor: |
Ju-Hua, Liu, Jian-Wei, Gu, Quan, Hu, Guo-Long, Yue, Lei, Liu, Xiang, Tu, Cheng-Shi, He, Ji-Ping, Du |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Zhen ci yan jiu = Acupuncture research. 45(6) |
| ISSN: |
1000-0607 |
| Popis: |
To observe the effect of catgut implantation at "Yingxiang"(LI20) on lower airway remodeling and levels of osteopon-tin (OPN) protein in allergic rhinitis (AR) rats, so as to reveal its mechanisms underlying improvement of AR.Male SD rats were randomly divided into control, model and catgut implantation groups, with 10 rats in each group. The AR model was established by intraperitoneal injection and nasal drip of ovalbumin. The catgut implantation was applied to bilateral "Yingxiang"(LI20) for 28 days in rats of the catgut implantation group. The total score of allergic symptoms of rats in each group were observed. The histopathological changes of lower airway were observed under light microscope after Hematoxylineosin, Periodic acid-Schiff and Masson staining. The expression of OPN protein was detected by immunohistochemistry and Western blot, separately.The total score of allergic symptoms of nose-wiping, running nose and sneezing, count of lung goblet cells, lung fiber content, and immunoactivity and expression levels of OPN protein were significantly increased in the model group in contrast to the control group (Acupoint implantation of catgut can improve pathological changes of lower airway remodeling, which may be related to its effect in down-regulating the expression of OPN protein in the lung tissue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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