Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ

Autor:	Nicole, Kopp, Gianluca, Civenni, Domenico, Marson, Erik, Laurini, Sabrina, Pricl, Carlo V, Catapano, Hans-Ulrich, Humpf, Carmen, Almansa, Francisco Rafael, Nieto, Dirk, Schepmann, Bernhard, Wünsch
Rok vydání:	2021
Předmět:	Analgesics Binding Sites Antineoplastic Agents Stereoisomerism Molecular Dynamics Simulation Ligands Disease Models Animal Mice Structure-Activity Relationship Hyperalgesia Cell Line Tumor Animals Humans Receptors sigma Thermodynamics Female Cell Proliferation Protein Binding Pyrans
Zdroj:	European journal of medicinal chemistry. 219
ISSN:	1768-3254
Popis:	1,3-Dioxanes 1 and cyclohexanes 2 bearing a phenyl ring and an aminoethyl moiety in 1,3-relationship to each other represent highly potent σ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b79dcdda2143d36fd4fcec0978938cd9 https://pubmed.ncbi.nlm.nih.gov/33901806 Zobrazit plný text záznamu Full Text from ScienceDirect