ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES

Autor:	Weaver, T.A., Charafeddine, A.H., Agarwal, A., Turner, A.P., Russell, M., Leopardi, F.V., Kampen, R.L., Stempora, L., Song, M., Larsen, C.P., Kirk, A.D.
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Sirolimus Immunoconjugates Recombinant Fusion Proteins T-Lymphocytes Graft Survival CD2 Antigens chemical and pharmacologic phenomena Alefacept Kidney Transplantation Macaca mulatta Article Abatacept Animals Transplantation Homologous Blood Transfusion Immunologic Memory
Zdroj:	Nature medicine
ISSN:	1546-170X 1078-8956
Popis:	Memory T cells promote allograft rejection particularly in co-stimulation blockade-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (lymphocyte function-associated antigen-3-Ig; LFA -3-Ig) selectively eliminates memory T cells and, when combined with a co-stimulation blockade-based regimen using cytotoxic T lymphocyte antigen-4 (CTLA-4)-Ig, a CD80- and CD86-specific fusion protein, prevents renal allograft rejection and alloantibody formation in nonhuman primates. These results support the immediate translation of a regimen for the prevention of allograft rejection without the use of calcineurin inhibitors, steroids or pan-T cell depletion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b78fe2cd9930f04952c1dad82a82c2b1 http://europepmc.org/articles/PMC2772128 Zobrazit plný text záznamu Plný text ve formátu PDF