Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor
| Autor: | R E, Harris, G A, Alshafie, H, Abou-Issa, K, Seibert |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Sulfonamides
Cyclooxygenase 2 Inhibitors 9 10-Dimethyl-1 2-benzanthracene Body Weight Ibuprofen Mammary Neoplasms Animal Rats Substrate Specificity Isoenzymes Rats Sprague-Dawley Celecoxib Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Animals Anticarcinogenic Agents Pyrazoles Cyclooxygenase Inhibitors Female |
| Zdroj: | Cancer research. 60(8) |
| ISSN: | 0008-5472 |
| Popis: | Nonsteroidal anti-inflammatory drugs (NSAIDs) have been observed to reduce the relative risk of breast cancer. This prompted our investigation of the chemopreventive potential of celecoxib, a specific cyclooxygenase 2 blocker, against mammary carcinogenesis induced by 7,12-dimethyl-benz(a)anthracene in female Sprague Dawley rats. Treatment with celecoxib was examined and compared to treatment with the general NSAID, ibuprofen, and to a control group receiving only dimethylbenz(a)anthracene. Dietary administration of celecoxib (1500 ppm) produced striking reductions in the incidence, multiplicity, and volume of breast tumors relative to the control group (68%, 86%, and 81%, respectively; P0.001). Ibuprofen also produced significant effects, but of lesser magnitude (40%, 52%, and 57%, respectively; P0.001). These results help confirm the chemopreventive activity of NSAIDs against breast cancer and provide the first evidence that a cyclooxygenase 2 blocking agent, celecoxib, possesses strong chemopreventive activity against mammary carcinogenesis. |
| Databáze: | OpenAIRE |
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