Head-to-head comparison of 1-week triple regimens combining ranitidine or omeprazole with two antibiotics to eradicate Helicobacter pylori

Autor:	V, Savarino, P, Zentilin, G, Bisso, M, Pivari, M R, Mele, G S, Mela, C, Mansi, S, Vigneri, R, Termini, G, Celle
Rok vydání:	1999
Předmět:	Adult Male Helicobacter pylori Humans Drug Therapy Combination Female Middle Aged Anti-Ulcer Agents Ranitidine Omeprazole Aged Anti-Bacterial Agents Helicobacter Infections
Zdroj:	Alimentary pharmacologytherapeutics. 13(5)
ISSN:	0269-2813
Popis:	Triple therapies containing omeprazole and ranitidine have been shown to be equivalent in eradicating H. pylori infection, but have been assessed either separately or head-to-head, only in small trials.To carry out a large randomized controlled study comparing omeprazole and ranitidine combined with two antibiotic combinations for 1 week.Three hundred and twenty H. pylori-positive patients were randomly subdivided into four equal-sized groups and received one of the following treatments: OAM = omeprazole 20 mg b.d. + amoxycillin 1 g b.d. + metronidazole 500 mg b.d.; RAM = ranitidine 300 mg b.d. + amoxycillin 1 g b.d. + metronidazole 500 mg b.d.; OAC = omeprazole 20 mg b.d. + amoxycillin 1 g b.d. + clarithromycin 250 mg t.d.s.; RAC = ranitidine 300 mg b.d. + amoxycillin 1 g b.d. + clarithromycin 250 mg t.d.s. The assessment of H. pylori status was performed before and 4 weeks after the end of therapy by means of CLO-test and histology. H. pylori infection was considered to be eradicated when both tests were negative.OAM and RAM eradicated H. pylori in 89% and 85% of cases on per protocol (P = 0.48) and in 77% and 75% of cases on intention-to-treat analyses (P = 0.71). OAC and RAC eradicated H. pylori in 67% and 70% of cases on per protocol (P = 0.68) and in 57% and 64% of cases on intention-to-treat analyses (P = 0.41). In contrast, there was significant difference between OAM and OAC (P0.01) and between RAM and RAC (P0.05). Side-effects occurred in 15%, 10%, 17% and 16% of patients with respect to the above four subgroups.Omeprazole and ranitidine combined with two antibiotics for 1 week are equally effective in the eradication of H. pylori infection, and these results question the role of profound acid suppression in the eradication of the bacterium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b76e2d7e5dd5ad4ba615389b8fe5395f https://pubmed.ncbi.nlm.nih.gov/10930908 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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