| Autor: |
Yu-Chieh, Lin, Yi-Yin, Lai, Hsiao-Ying, Liu, Yen-Chin, Chen, Li-Fang, Liu, Nai-Ying, Ko |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Hu li za zhi The journal of nursing. 67(1) |
| ISSN: |
0047-262X |
| Popis: |
Early antiretroviral therapy (ART) is recommended as an intervention for HIV by the World Health Organization. However, the association between the CD4 count at ART initiation and the risk of adverse drug reactions (ADRs) remains unclear.This study aimed to describe the trends related to symptom number and intensity among patients newly diagnosed with HIV in three different CD4-count-based groups and then to investigate the ADR trends for these three groups at different points in time.This multi-center cohort study recruited newly diagnosed HIV/AIDS patients who had not previously used ART from AIDS-designated hospitals in Taiwan from March 2015 to December 2016. Study measures were assessed at the time of case enrollment (T0) and during the 1st month (T1), 4-6th month (T2), and 7-9th month (T3) of ART treatment. Patients were stratified into three groups according to initial CD4 count: ≤ 350 cells/mmA total of 207 patients completed the study. Mean symptom numbers and symptom intensities decreased significantly over time in all three groups (p.01). The largest mean reduction in both symptom number and intensity was achieved by the CD4 count500 cells/mmNumber and intensity of symptoms significantly improved over time in all three CD4 count groups. The percentage of systematic side effects was most reduced in the CD4 count500 cells/mm初診斷愛滋感染者接受抗病毒藥物治療之免疫力與副作用趨勢變化.世界衛生組織（World Health Organization）於2016年更新愛滋病治療指引，呼籲一旦確立診斷後，不論CD4數值，即可進行治療。然而HIV感染者在初服藥時的免疫力與副作用之變化尚未清楚。.初診斷愛滋感染者依據其初服藥CD4數值分為三組：CD4 ≤ 350 cells/mm採多中心世代研究法，於2015年3月至2016年12月間，針對初次服藥的愛滋感染者，於基準值（T0）、服藥後1個月（T1）、4-6個月（T2）及7-9個月（T3）四個時間點，進行症狀評估，並依據其初服藥CD4數值分為三組，以重複測量單因子變異數分析以及廣義估計式進行結果分析。.共207位感染者完整追蹤至T3，隨時間變化三組之平均症狀數及平均症狀強度總分均顯著下降，且皆以CD4數值500 cells/mm無論初服藥時CD4數值，其症狀數與症狀強度總分均隨著時間有明顯改善，其中以CD4500 cells/mm |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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