| Autor: |
Carmen, Pérez Morales, M, Mar Herrador, José F, Quílez del Moral, Alejandro F, Barrero |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Natural product communications. 10(1) |
| ISSN: |
1934-578X |
| Popis: |
Following the principles of collective total synthesis, a number of natural products sharing an optically pure, multifunctional, cyclopentanic core were synthesized from a common precursor: plinol A (1). This intermediate was efficiently obtained in only four steps from (-)-linalool (2) using as the key step a Ti(III)-mediated diastereoselective radical cyclization. The feasibility of this approach was confirmed with the expedient enantiospecific synthesis of cyclonerodiol (3), and the formal synthesis of chocol G (4) and piperitone (5). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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