| Autor: |
J, Haan, C, Kluft, F W, Leebeek, A C, de Bart, O J, Buruma, R A, Roos |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Thrombosis and haemostasis. 67(1) |
| ISSN: |
0340-6245 |
| Popis: |
In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII:Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII:Ag level in the acute phase is unclear. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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