| Autor: |
Iu V, Vakhitova, M Kh, Salimgareeva, S V, Sibiriak, N N, Kurchatova, S B, Seredin |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 67(5) |
| ISSN: |
0869-2092 |
| Popis: |
The effects of ladasten on the activation-induced expression of Fas-receptor on T-lymphocytes, their sensitivity to Fas-induced apoptosis, and the expression of mitogen-activated ERKI/ERK2 protein kinases have been studied. In the range of concentrations 0.1-10 microM, ladasten exhibited a comitogenic effect on the TCR-mediated stimulation of T-lymhocytes ion the peripheral human blood, which was accompanied by an increase in the level of phosphorylated form of ERK-2. At the same time, ladasten virtually did not change the activation-induced expression of Fas-receptor on T-lymphocytes, but reduced the rate of the Fas-induced apoptosis. It was concluded that the immunoprotective effect of ladasten is probably based on a decrease in the rate of Fas-induced apoptosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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