| Autor: |
M, Iizuka, Y, Morita, T, Ishida, H, Shiraishi, S, Morisawa, N, Ishida, H, Fujita, Y, Yagi, K, Jobu, M, Miyamura |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Die Pharmazie. 73(12) |
| ISSN: |
0031-7144 |
| Popis: |
Ulinastatin vaginal suppositories, used to prevent threatened premature delivery, are frequently used in hospitals. However, there is no established method for quantifying ulinastatin contained in suppositories. Therefore, we investigated a simple and efficient method for quantifying ulinastatin contained in suppositories. Our analytical method involved removal of the base; optimising the enzyme inhibition reaction time and enzyme reaction time; and measuring the absorbance. The modified method was reproducible, operation time was significantly shortened, and cost was reduced to approximately 1/17 of that of the previously reported method. This simple and rapid quantitative method could contribute to the improvement of quality control of ulinastatin vaginal suppositories as an extemporaneous hospital preparation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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