[Ca(2+)-dependent regulation of T-lymphocytes in experimental tuberculosis]

Autor: S V, Demidov, A P, Kostromin, E F, Chernushenko, V V, Kuibeda, M I, Borovik
Rok vydání: 1991
Předmět:
Zdroj: Problemy tuberkuleza. (6)
ISSN: 0032-9533
Popis: Ca(2+)-exchange kinetics and the content of membrane and cytoplasm fractions of calmodulin in the splenic T-lymphocytes of guinea pigs with experimental tuberculosis were studied. A tuberculous process was accompanied by the changes in the Ca2+ exchange kinetics in the form of T-lymphocyte oversaturation with Ca2+ ions which in the end leads to an inhibition of the functional status of the immunity T system. PPD, a specific allergen, brought the capacity of T lymphocytes down in relation to the cellular Ca2+ exchange, presumably causing the normalization of the immune response.
Databáze: OpenAIRE