| Autor: |
Christos A, Papanastasiou, Damianos G, Kokkinidis, Polydoros N, Kampaktsis, Iosif, Bikakis, Daniela K, Cunha, Evangelos K, Oikonomou, John P, Greenwood, Mario J, Garcia, Theodoros D, Karamitsos |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
JACC. Cardiovascular imaging. 13(2 Pt 1) |
| ISSN: |
1876-7591 |
| Popis: |
The aim of this systematic review was to explore the prognostic value of late gadolinium enhancement (LGE) in patients with aortic stenosis (AS).Myocardial fibrosis is a common feature of many cardiac diseases. Cardiac magnetic resonance (CMR) has the ability to noninvasively detect regional fibrosis by using the LGE technique. Several studies have explored whether LGE is associated with adverse outcome in patients with AS.Electronic databases were searched to identify studies investigating the ability of LGE to predict all-cause mortality in patients with AS. A random effects model meta-analysis was conducted. Heterogeneity was assessed with the ISix studies comprising 1,151 patients met our inclusion criteria. LGE was present in 49.1% of patients with AS. In the pooled analysis, LGE was found to be a strong univariate predictor of all-cause mortality (pooled unadjusted odds ratio: 2.56; 95% confidence interval: 1.83 to 3.57; IFibrosis on LGE-CMR is a powerful predictor of all-cause mortality in patients with AS and may serve as a novel marker for risk stratification. Future studies should explore whether LGE-CMR can also be used to optimize timing of AS-related interventions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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