[Incidence of pneumonia in HIV-infected patients in the highly active antiretroviral therapy era]

Autor: María, Velasco Arribas, José Angel, Satué Bartolomé, Juan Emilio, Losa García, Alfredo, Espinosa Gimeno, Alberto, Delgado-Iribarren, Virgilio, Castilla Castellano
Rok vydání: 2007
Předmět:
Zdroj: Medicina clinica. 128(4)
ISSN: 0025-7753
Popis: There is scant data comparing the incidence of pneumonia in the community and in the human immunodeficiency virus (HIV) population in highly active antiretroviral therapy (HAART) era.Prospective study during 18 months. Data were obtained by the means of the electronic clinical record. Incidence rate was compared between HIV positive and negative patients.There were 529 pneumonia episodes in global population (n = 220,000), 1.6 cases/1000 person-year. HIV-infected patients (n = 170) suffered 12 episodes of pneumonia; 46 cases/1000 person-year (relative risk = 29.3, 95% confidence interval, 16.34-51.4; p0.01). HIV infected patients with pneumonia have a lower CD4 count (mean 434 versus 230 cells/ml; p = 0.04), higher viral load (4.1 versus 3.2 log copies/ml; p = 0.07) and received antiretroviral treatment in a similar proportion compared to HIV without pneumonia (62 versus a 66.7%, p = 0.5).Pneumonia in HIV infected patients may be about 30 times more frequent than general population in HAART era. Prevention measures should be reinforced.
Databáze: OpenAIRE