Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda

Autor:	I O, Mondranondra, C T, Che, A M, Rimando, S, Vajrodaya, H H, Fong, N R, Farnsworth
Rok vydání:	1990
Předmět:	Lactones Aporphines Glucosides Phenylpropionates Plant Extracts Tumor Cells Cultured Animals Antineoplastic Agents Phytogenic Sesquiterpenes
Zdroj:	Pharmaceutical research. 7(12)
ISSN:	0724-8741
Popis:	The pentane and CHCl3 fractions of a crude extract of Michelia floribunda exhibited cytotoxic activity when tested in KB and P388 tumor cell cultures. Repeated chromatography led to the isolation of three cytotoxic sesquiterpene lactones (costunolide, parthenolide, and santamarine) and a cytotoxic isoquinoline alkaloid (liriodenine). Inactive sesquiterpene lactones obtained during the course of this study included dihydroparthenolide and two new glucosides of dihydrotamaulipin A and dihydroreynosin (1 and 2). The structures of these new compounds were determined through interpretation of their spectroscopic data including 2D-NMR spectroscopy. Syringin was also isolated from the extract.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b66dd9acba2f0d623647c613aa943514 https://pubmed.ncbi.nlm.nih.gov/2095565 Zobrazit plný text záznamu Full text from SpringerLink