| Autor: |
Aleksandra, Kawczyk-Krupka, Zenon Pawel, Czuba, Beata, Kwiatek, Sebastian, Kwiatek, Magdalena, Krupka, Karolina, Sieroń |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Photodiagnosis and photodynamic therapy. 19 |
| ISSN: |
1873-1597 |
| Popis: |
The most fundamental problem in cancer biology research is to understand the mechanisms of cancer cell resistance to oncological therapies. Literature reports emphasize the important role of adhesion molecules: intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 (ICAM-1 and VCAM-1) in cancer progression and resistance to treatment. Photodynamic therapy (PDT) could become the component of a personalized approach to colorectal cancer, therefore we examined the effects of ALA (δ-aminolevulinic) acid PDT in normoxia and under cobalt chloride (CoClHuman colorectal cancer cells of different malignant potential SW480 and SW620 were used in the experiment. Cell lines were treated ALA, in order to achieve conditions comparable to in vivo hypoxia, CoClThe experiment revealed that ALA PDT under normoxia and CoClDetermination of tumor marker levels and especially adhesion molecules involved in metastatic spread is necessary. Our experiment reveals, that ALA PDT in normoxia and CoCl |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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