Phosphotyrosine-protein-phosphatases and human reproduction: an association between low molecular weight acid phosphatase (ACP1) and spontaneous abortion

Autor:	F, Gloria-Bottini, M, Nicotra, N, Lucarini, P, Borgiani, M, La Torre, A, Amante, A, Gimelfarb, E, Bottini
Rok vydání:	1996
Předmět:	Adult Genetic Markers Male Abortion Habitual Polymorphism Genetic Genotype Reproduction Infant Newborn Isoenzymes Pregnancy Case-Control Studies Proto-Oncogene Proteins Humans Female Protein Tyrosine Phosphatases Alleles
Zdroj:	Disease markers. 12(4)
ISSN:	0278-0240
Popis:	ACP1 (low molecular weight acid phosphatase) genetic polymorphism has been studied in 173 women with a history of two or more consecutive spontaneous abortions and in 1508 control subjects, including 482 normal pregnant women. The proportion of carriers of ACP1*C allele (*A/ *C, *B/*C) in women with a history of repeated spontaneous abortion is lower than in normal pregnant women and other control groups. Women with repeated spontaneous abortion show a specific decrease of ACP1 S isoform concentration as compared to normal pregnant women. The other component of ACP1 activity, the F isoform, does not show a significant difference between the two groups. The data suggest that women with ACP1 genotypes showing a high concentration of S isoform are relatively 'protected' against spontaneous abortion. Preliminary analysis of a sample of 352 normal puerperae along with their newborn babies supports this hypothesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b62de9967ae2c2b45a03fa4534b7c6d6 https://pubmed.ncbi.nlm.nih.gov/8718786 Zobrazit plný text záznamu Plný text