| Autor: |
Ryuichi, Totsuka, Takaaki, Kondo, Shigeki, Matsubara, Midori, Hirai, Yoichi, Kurebayashi |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
The Kobe journal of medical sciences. 62(2) |
| ISSN: |
1883-0498 |
| Popis: |
VLA-1 (very late antigen-1) is implicated in recruitment, retention and activation of leukocytes and its blockade has been referred as a potential target of new drug discovery to address unmet medical needs in inflammatory disease area. In the present study, we investigate the effects of an anti-murine CD49a (integrin α subunit of VLA-1) monoclonal antibody (Ha31/8) on various experimental models of inflammatory diseases in mice. Pretreatment with Ha31/8 at an intraperitoneal dose of 250 μg significantly (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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