IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer
| Autor: | Jiao, Song, Ni, Zhang, Liang, Zhang, Hengjing, Yi, Yi, Liu, Yanxi, Li, Xuelin, Li, Meng, Wu, Lan, Hao, Zhu, Yang, Zhigang, Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ovarian Neoplasms
Mice Inbred BALB C Indoles photothermal therapy Cell Survival Infrared Rays Mice Nude Hyperthermia Induced Phototherapy imaged-guide surgery nanomedicine Fluorescence Folic Acid ovarian cancer Surgery Computer-Assisted Cell Line Tumor Liposomes Animals Humans Nanoparticles Female Tissue Distribution IR780 iodide Original Research |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Background and purpose: Surgery is regarded as the gold standard for patients with advanced ovarian cancer. However, complete surgical removal of tumors remains extremely challenging; fewer than 40% of patients are cured. Here, we developed a new modality of theranostics for ovarian cancer based on a near-infrared light-triggered nanoparticle. Methods: Nanoparticles loading IR780 iodide on base of folate modified liposomes were prepared and used for theranostics of ovarian cancer. Tumor targeting of FA-IR780-NP was evaluated in vitro and in an ovarian xenograft tumor model. A fluorescence stereomicroscope was applied to evaluate the tumor recognition of FA-IR780-NP during surgery. FA-IR780-NP mediated photothermal therapy effect was compared with other treatments in vivo. Results: FA-IR780-NP was demonstrated to specifically accumulate in tumors. IR780 iodide selectively accumulated in tumors; the enhanced permeability and retention effect of the nanoparticles and the active targeting of folate contributed to the excellent tumor targeting of FA-IR780-NP. With the aid of tumor targeting, FA-IR780-NP could be used as an indicator for the real-time delineation of tumor margins during surgery. Furthermore, photothermal therapy mediated by FA-IR780-NP effectively eradicated ovarian cancer tumors compared with other groups. Conclusion: In this study, we present a potential, effective approach for ovarian cancer treatment through near-infrared fluorescence image-guided resection and photothermal therapy to eliminate malignant tissue. |
| Databáze: | OpenAIRE |
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