| Autor: |
Shan-Shan, Ma, Seong-Hyun, Ho, Hong-Ling, Wang, Li-Ya, Nie, Song-Shan, Xu |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 24(5) |
| ISSN: |
1009-2137 |
| Popis: |
To evaluate the effect of PEGylated IL-11 mutein (PEG-mIL 11) with different dose or injection frequency on thrombocytopenia in myelosuppressed mice and to compare its effect with mIL-11, so as to provide reference data for clinical use.Myelosuppressive model with thrombocyopenia was produced in BALB/c mice by whole bodyAfterA preventive effect of PEG-mIL 11 on thrombocytopenia in myelosuppressed mice has been confirmed. In comparison with mIL-11, a better effect of PEG-mIL 11 is obtained under lower dose frequency, indicating a better compliance of the treatment regimen, and providing a foundation for developing a long-acting preparation of rhIL-11. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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