Combining targeted therapy with immunotherapy (interferon-α)

Autor:	Chen, Lei L., Gouw, Launce, Sabripour, Mahyar, Hwu, Wen-Jen, Benjamin, Robert S.
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	peginterferon α-2b drug-resistance interferon-α imatinib immunotherapy targeted therapy neoplasms Author's View gastrointestinal stromal tumor
Zdroj:	Oncoimmunology
ISSN:	2162-402X 2162-4011
Popis:	Imatinib revolutionized gastrointestinal stromal tumor (GIST) treatment but median-progression-free-survival of unresectable/metastatic disease is < 2 y. B-RAFV600-mutated-melanoma responds to vemurafenib dramatically but median-progression-free-survival is < 9 mo. Combining imatinib with immunotherapy (peginterferon α-2b) in GIST showed significant induction of antitumor immunity and highly promising clinical outcomes. This strategy warrants further testing in other malignancies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b5cc1c825c11007a7faab5126496b9b6 http://europepmc.org/articles/PMC3429591 Zobrazit plný text záznamu