Feasibility of peripheral blood stem cell rescue as intensification in elderly patients with acute myelocytic leukaemia: a pilot study from the Gimema Group. Gruppo Italiano Malattie Ematologiche Maligne Dell'Adulto

Autor:	M, Montillo, A, Tedeschi, L, Pagano, A, Venditti, F, Ferrara, P, Fabris, B, Martino, M, Musso, G, De Rosa, G, Specchia, M, Monaco, G, Sparaventi, A, Spadea, A, Palmas, W, Deplano, A, Manna, L, Melillo, E, Miraglia, S, Mirto, F, Mandelli
Rok vydání:	2000
Předmět:	Aged 80 and over Male Remission Induction Hematopoietic Stem Cell Transplantation Pilot Projects Middle Aged Transplantation Autologous Leukemia Myeloid Acute Disease Granulocyte Colony-Stimulating Factor Feasibility Studies Humans Female Aged
Zdroj:	British journal of haematology. 111(1)
ISSN:	0007-1048
Popis:	Elderly patients with untreated acute myeloid leukaemia (AML, n = 47) tested the feasibility of out-patient consolidation therapy and post-consolidation treatment (for patients aged71 years) with autologous peripheral blood stem cell transplantation (APBSCT). Overall, 13 patients out of 24 (51%) who achieved complete remission (CR) were eligible for further treatment after consolidation. Five patients were primed with granulocyte colony stimulating factor (G-CSF); a suitable number of CD34+ cells were harvested in three patients and were actually autotransplanted. The toxicity of APBSCT was negligible. Psychosocial problems impaired treatment of some patients on an out-patient basis. Resistant disease, toxicity and logistic problems reduced the number of patients to whom this procedure could actually be applied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b5c96654971116715726c58ab8d5c36a https://pubmed.ncbi.nlm.nih.gov/11091221 Zobrazit plný text záznamu Plný text