| Autor: |
Young Sup, Woo, Won-Myong, Bahk, Moon Yong, Chung, Do-Hoon, Kim, Bo-Hyun, Yoon, Jong Hun, Lee, Yong Min, Ahn, Sang-Keun, Chung, Jeong-Gee, Kim, Kwang Heun, Lee, Ki-Chung, Paik |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Human psychopharmacology. 26(8) |
| ISSN: |
1099-1077 |
| Popis: |
The goal of this study was to investigate the safety and efficacy in preventing relapse of a mood episode in recently manic or mixed episode patients with bipolar I disorder stabilized with aripiprazole and divalproex combination.This randomized, 24-week, double-blind, placebo-controlled multicenter study enrolled patients from 23 centers in Korea. Patients with bipolar I disorder who had manic or mixed episode entered a 6-week open-label stabilization phase. After meeting stabilization criteria, 83 patients were randomly assigned to placebo + divalproex or aripiprazole + divalproex treatment group for the 24-week, double-blind maintenance phase.During the 6-month double-blind treatment, the time to relapse of any mood episode in the aripiprazole group was longer than the placebo group, but the difference did not reach statistical significance (p = 0.098). After controlling for mean divalproex level, the time to depressive episode relapse in the aripiprazole group was longer than those in the placebo group (p = 0.029). Weight gain (≥ 7% increase) occurred in 22.5% aripiprazole group and 18.6% placebo group (p = 0.787).In this study, relapse of mood episode occurred fewer and later for aripiprazole with divalproex treatment than divalproex monotherapy, but the differences were not statistically significant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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