| Autor: |
Sohei, Matsumoto, Yukishige, Yamada, Michihiro, Narikiyo, Masato, Ueno, Hidetoshi, Tamaki, Katsuhiko, Miki, Kohei, Wakatsuki, Koji, Enomoto, Tomoyo, Yokotani, Yoshiyuki, Nakajima |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Anticancer research. 27(4B) |
| ISSN: |
0250-7005 |
| Popis: |
Cancer metastases are commonly found in the lymphatic system and tumor lymphangiogenesis requires the interplay of several growth factors. The expression of platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C in esophageal cancer was investigated to define their clinicopathological significance.Using immunohistochemistry, the expression of PDGF-BB and VEGF-C was examined, along with lymphatic vessel density (LVD) in 53 patients with esophageal cancer.PDGF-BB and VEGF-C expression was positive in 31 cases (58.5%) and 38 cases (71.7%), respectively, and expression correlated with lymph node metastasis and lymphatic invasion. Furthermore, PDGF-BB expression correlated with the depth of tumor invasion and the size of the tumor, and PDGF-BB-positive patients had a significantly poorer prognosis than PDGF-BB-negative patients. The LVD in positive PDGF-BB or VEGF-C tumors was higher than in negative tumors.PDGF-BB may play a pivotal role in lymphangiogenesis and tumor growth in esophageal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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