| Autor: |
E, Cazorla, A, Urgal, J, Córdoba, A, Boldó, M, Marín, M, Sánchez Gutiérrez, J M, Molina, J, Llixiona |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 18(1) |
| ISSN: |
0214-3429 |
| Popis: |
The aim of this study was to evaluate the long-term efficacy of beta-interferon treatment in the management of cervical intraepithelial neoplasia associated with human papillomavirus (HPV) infection in a selected group of patients. Thirty-nine patients who had histologically proven cervical intraepithelial neoplasia I or II with concurrent HPV infection were administered 27,000,000 IU of intramuscular beta-interferon. Periodical controls were carried out based on Papanicolaou smears and/or colposcopic examination and DNA HPV determination was performed by hybridation test, for a maximum of 8 years' follow-up. An initial complete response rate of 75% was obtained, with a recurrence rate of 25%, cervical intraepithelial neoplasia with late manifestation was of higher grade. Treatment interruption due to side-effects was not necessary. Associated viral infections appeared to be a recurrence risk factor, but not smoking or parity. While immunomodulatory treatment with beta-interferon has good long-term results in cervical intraepithelial neoplasia I/II treatment, wider randomized studies are required to obtain conclusive results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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