| Autor: |
G, Torres, M, Paredes, A, Hernández, C, García, F, Sánchez Bueno, M, Canteras, P, Parrilla, J, Gómez |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 30(1) |
| ISSN: |
1988-9518 |
| Popis: |
To study a cohort of patients with intra-abdominal postsurgical infection treated with tigecycline to analyze its effectiveness and mortality related factors.Prospective study of patients with intra-abdominal postsurgical infection with microbiological isolation and treated with tigecycline.Out of 103 patients only 61 full fit inclusion criteria. Mean age was 67 year-old and 72% were male. Charlson score was ≥ 3 in 65.5%, being diabetes and colon cancer the most prevalent diseases. Cancer surgery was the most frequent procedure (n=44, 72%) and previous antibiotic administration was present in 43 cases (69%). Pitt score was ≥ 3 in 69% and most prevalent bacteria were Escherichia coli (38 %), Enterococcus spp. (34%; mainly Enterococcus faecium) and Klebsiella pneumoniae together with Enterobacter cloacae (28%). Tigecycline was prescribed alone (17; 28%) or in combination with other antibiotics (44; 72%), mainly meropenem (25; 57%) or amikacin (19, 43%). 11 patients died (18%), all of which suffered extended cancer surgery and isolation of extended-spectrum betalactamase producing Enterobacteriaceae. Factors statistically associated to death in univariate analysis were Charlson score3, pH7.3 and leucocyte count20.000 cells/mm3.As being a cohort of patients treated with tigecycline, E. faecium isolation was very frequent. Non-fatal evolution was achieved in 82% cases, being tigecycline a potentially good option in the empiric treatment of very severe infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
