| Autor: |
G W, Brumbaugh, L E, Davis, J C, Thurmon, D C, Savage |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
American journal of veterinary research. 51(5) |
| ISSN: |
0002-9645 |
| Popis: |
Opsonized Rhodococcus equi activated the respiratory burst of resident alveolar macrophages (AM) from adult horses in a logarithmic-linear, mass-related manner. The effect of R equi was not significantly different from that of equal masses of opsonized zymosan A. Therefore, R equi does not appear to attenuate the respiratory burst of equine AM. The stimulatory effect of R equi was not reflected by increased production of superoxide anion (O2-), but increased activity of the hexose monophosphate shunt was observed. These results suggest a similarity between the respiratory burst of AM from horses and that of AM from rabbits. We concluded that resident AM from adult horses do not produce O2- concurrently with an increase in activity of the hexose monophosphate shunt when stimulated with either opsonized zymosan A or opsonized R equi. This suggests that O2- is not an important component of the antibacterial defenses of equine AM. Whether equine AM are incapable of producing O2- or require different stimuli to produce it was not determined. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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