Mannose-binding protein gene polymorphism in systemic lupus erythematosus

Autor:	E J, Davies, N, Snowden, M C, Hillarby, D, Carthy, D M, Grennan, W, Thomson, W E, Ollier
Rok vydání:	1995
Předmět:	Adult Male Polymorphism Genetic Adolescent Base Sequence Molecular Sequence Data Complement System Proteins Middle Aged Mannose-Binding Lectins Gene Frequency Humans Lupus Erythematosus Systemic Female Carrier Proteins Child Alleles Aged
Zdroj:	Arthritis and rheumatism. 38(1)
ISSN:	0004-3591
Popis:	To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE).MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls.The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3).Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b556804b51bfc00dd6b4db975cd904b2 https://pubmed.ncbi.nlm.nih.gov/7488298 Zobrazit plný text záznamu Plný text