| Autor: |
P, Joret-Descout, J, Bataille, F, Brion, O, Bourdon, J-F, Hartmann, S, Prot-Labarthe |
| Jazyk: |
francouzština |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Annales pharmaceutiques francaises. 74(3) |
| ISSN: |
0003-4509 |
| Popis: |
The lack of drugs specifically assessed for paediatric use results in a widespread off-label drug use. The aim of this work is to identify experiences and attitudes towards paediatrics off-label prescribing in a university teaching paediatric hospital.A questionnaire of 24 items was sent by email to 409 paediatricians in February 2013.frequency of off-label prescribing, sources of information, concern about safety and adverse events with off-label drug use, proportion of parents informed and order with "off-label" mention.Eighty questionnaires were returned. Over 81% of responders were familiar with the concept of off-label drugs prescribing. The most common reason given for off-label prescribing was for a younger age (74%) and for another indication (28%). They (79%) used a colleague's opinion and the most important sources of information used were the literature (72%), international guidelines (62%), the French National Formulary Vidal (56%) and national guidelines (46%). Although 54% of responders expressed concerns about safety about off-label prescription, only 29% had observed adverse event with off-label drug use. Two third of respondents informed the parents but off-label prescribing cannot be always explained to family. Many respondents (81%) did not write "off-label" mention on prescription. However, 52% stated that they would be willing to undertake off-label prescription monitoring with a local observatory.Our study describes the perceptions and attitudes of paediatrician's regarding off-label prescribing for children. Patient information and documentation in the patient file remain incomplete. The prospective collection of off-label prescription will locally be performed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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