| Autor: |
J, Allard, D P, Lennon, M R, Greenwood, A J, Buckenham, J N, Hawthorne |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Biochimica et biophysica acta. 1220(1) |
| ISSN: |
0006-3002 |
| Popis: |
HL-60 cells were cultured in normal and inositol-deficient media. The inositol-deficient cells showed reduced sodium pump activity, as measured by ouabain-sensitive 86Rb+ uptake. The protein kinase C inhibitors staurosporine and H7 did not affect uptake in either normal or inositol-deficient cells. However, U73122, a steroidal inhibitor of phosphoinositidase C, inhibited uptake in both types of cells. Activators of protein kinase C had no effect on Rb+ entry. The inositol deficiency is not considered to affect the sodium pump by a mechanism involving diacylglycerol and protein kinase C. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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