Synthesis of new 1-aryl-6-benzylimidazo[1,2-a][1,3,5]triazines with potential pharmacological activity

Autor: Marzena, Rzadkowska, Elzbieta, Szacoń, Dariusz, Matosiuk, Ewa, Kedzierska, Sylwia, Fidecka
Rok vydání: 2013
Předmět:
Zdroj: Acta poloniae pharmaceutica. 69(6)
ISSN: 0001-6837
Popis: In the reaction of ethyl N-(1-arylimidazolidine-2-ylidene) carbamic acid ester with 4-chlorobenzylamine new derivatives of 1-(1-arylimidazolidine-2-ylidene)-3-arylurea (I-VI) were obtained. Cyclic derivatives of dihydroimidazo[l ,2-a][1,3,5]trizines were synthesized by condensation of 1-(1-arylimidazolidine-2-ylidene)-3-(4-chlorobenzyl)urea with carbonyldiimidazole (CDI) (VII-XII). The effect of compounds X, XI on the central nervous system of mice in some behavioral tests was investigated.
Databáze: OpenAIRE