Detecting gene-environment interactions using a case-control design

Autor:	A M, Goldstein, R T, Falk, J F, Korczak, J H, Lubin
Rok vydání:	1997
Předmět:	Gene Frequency Risk Factors Case-Control Studies Sample Size Genetic Diseases Inborn Odds Ratio Humans Environment
Zdroj:	Genetic epidemiology. 14(6)
ISSN:	0741-0395
Popis:	We assessed the sample size required for detecting gene-environment (G x E) interactions in a case-control study of complex diseases. The results suggest that large numbers of cases and controls will be required to detect G x E interaction for some odds ratio and exposure frequency combinations. These and other results suggest that alternative study designs may be needed to detect G x E interaction particularly with rare genes or uncommon environmental exposures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b49f3e0001b39ed5bd4f23ca62a95d38 https://pubmed.ncbi.nlm.nih.gov/9433628 Zobrazit plný text záznamu Plný text