Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis

Autor:	A, Mamoune, V, Durand, P, Le Goff, Y L, Pennec, P, Youinou, R, Le Corre
Rok vydání:	2000
Předmět:	Arthritis Rheumatoid CD4-Positive T-Lymphocytes T-Lymphocytes Humans Leukocyte Common Antigens Protein Isoforms Tissue Distribution fas Receptor CD8-Positive T-Lymphocytes Immunophenotyping
Zdroj:	Histology and histopathology. 15(2)
ISSN:	0213-3911
Popis:	CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b46798ebf4fde381744b8c8ae983b266 https://pubmed.ncbi.nlm.nih.gov/10809380 Zobrazit plný text záznamu