| Autor: |
P G, Haines, C, Crawley, M C, Chetty, H, Jarvis, S E, Coles, J, Fisher, A, Nicolaou, G W, Stewart |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
British journal of haematology. 112(2) |
| ISSN: |
0007-1048 |
| Popis: |
Two families with inherited abnormalities in Na and K transport across the red cell membrane are described. Both presented with 'pseudohyperkalaemia' as a result of loss of K from the red cells on storage at room temperature. Routine haematology was essentially normal, except for macrocytosis in one family. Studies of the temperature dependence of the passive leak to K showed a novel shoulder pattern with a minimum at 25 degrees C, a maximum at 10 degrees C, followed by a further fall. As in other cases of red cell-based pseudohyperkalaemia, the abnormal temperature dependence of this 'leak' flux could be held to account for the loss of K from the cells at room temperature. These cases represent a novel variant of the temperature dependence of the passive leak of K and Na across the red cell membrane, and can be classified as a mild, non-haemolytic form of the group known as the hereditary stomatocytosis and allied disorders'. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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