Common p2y
| Autor: | Céline, Verdier, Jean-Bernard, Ruidavets, Annelise, Genoux, Guillaume, Combes, Vanina, Bongard, Dorota, Taraszkiewicz, Michel, Galinier, Meyer, Elbaz, Jean, Ferrières, Laurent O, Martinez, Bertrand, Perret |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Receptors Purinergic P2 Proteins Coronary Artery Disease Middle Aged Polymorphism Single Nucleotide Phenotype Gene Frequency Heart Rate Risk Factors Case-Control Studies Mutation Humans Genetic Predisposition to Disease France Biomarkers Genetic Association Studies Adiposity Aged Lipoprotein(a) |
| Zdroj: | Archives of cardiovascular diseases. 112(2) |
| ISSN: | 1875-2128 |
| Popis: | The P2YTo evaluate whether p2yDirect sequencing of the p2yCarriers of the rs3732757 261T and rs1466684 557G alleles represented 9% and 27.5% of the entire population, respectively. The allele frequencies were identical in patients with coronary artery disease and control subjects. The presence of 261T was associated with higher concentrations of plasma lipoprotein A-I and inhibitory factor 1, increased fat mass and a lower heart rate. Moreover, the proportion of patients with coronary artery disease with a pejorative systolic ankle-brachial index was lower in carriers of the 261T allele. In both populations, the 557G allele was associated with increased concentrations of lipoprotein(a), and an allele dose effect was observed.Two frequent p2y13 variants are associated with specific bioclinical markers of cardiovascular risk. Although neither one of these variants appears to be related to the development of atherosclerotic disease, they may modulate the risk of additional cardiovascular complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect