| Autor: |
Hui, Chen, Yan-Zhong, Chen, Qing-Chun, Xie, Shi-Yuan, Lin, Jia-Cheng, Lin, Wei-Ning, Jianc |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 36(7) |
| ISSN: |
1001-4454 |
| Popis: |
To prepare Shuxiong pulsatile controlled-release dropping pill and study the influencing factors in vitro.Dropping pills with suitable size (10 - 15 mg) were coated with swelling layer containing croscarmellose sodium and controlled-release layer containing ethylcellulos aqueous dispersion respectively to prepare Shuxiong pulsatile controlled-release dropping pill. The effects of the materials of swelling layer, the weight of swelling layer and controlled-release layer on the release of drugs were investigated to optimize the process technology and validate formula.The release behavior was influenced strikingly by the types and weight of coating layer. The optimal formula was as follows: Shuxiong pulsatile controlled-release dropping pills were prepared using croscarmellose sodium as inner layer with 15% (weight) coating level and ethylcellulose aqueous dispersion (Surelease) as outer controlled-release layer with 7% (weight) coating level. The lag time of prepared pulsatile controlled-release dropping pills was about 4 h and accumulative release rate reached 80% within 4 h.The drug release of Shuxiong pulsatile controlled-release dropping pill is shown in pulsatile way in vitro. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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