| Autor: |
P, Vague, G, Ramahandridona, C, Di Campo-Rougerie, F, Mahmoud |
| Rok vydání: |
1975 |
| Předmět: |
|
| Zdroj: |
Diabetemetabolisme. 1(3) |
| ISSN: |
0338-1684 |
| Popis: |
The collection every 15 seconds of the portal effluent of the isolated and perfused rat pancreas permitted the following observations: while the insulin response to tolbutamide (250 or 125 mug/ml) occurred immediately, that to glucose (15 mM), or to 1-leucine (15 mM) was delayed by 60-90 seconds. The response to d-glyceraldehyde occurred slightly but significantly more quickly than that of glucose. The response to alpha-keto-isocaproate was an intense and immediate one. Isovalerate elicited no insulin discharge. These results suggest that d-glucose and l-leucine have to be metabolized to stimulate insulin secretion and that alpha-keto-isocaproate seems to be a direct and specific signal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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