| Popis: |
To study the effect of transcutaneous electrical acupoint stimulation (TEAS) in the treatment of asthenozoospermia.We randomly divided 72 asthenozoospermia patients into a 2 Hz TEAS (n = 29), a 100 Hz TEAS (n = 20), and a blank control group (n = 23), those in the former two groups treated by 30 minutes of TEAS at 2 Hz and 100 Hz respectively, applied to the acupoints of bilateral Shenshu, left Zusanli, and Guanyuan, once a day for 60 days, while those in the blank control group left untreated. Using computer-assisted sperm analysis (CASA), we examined sperm concentration and motility as well as the percentages of grade a and grade a+b sperm in different groups of the patients.Compared with the baseline, 2 Hz TEAS significantly increased sperm motility (［12.76 ± 1.39］ vs ［18.89 ± 2.46］%, P0.05) and the percentage of grade a+b sperm ( ［10.68 ± 1.22］ vs ［16.32 ± 2.10］%, P0.05) in the asthenozoospermic patients, while 100 Hz TEAS improved not only sperm motility (［12.32 ± 2.21］ vs ［23.81 ± 3.42］%, P0.01) and the percentage of grade a+b sperm (［10.45 ± 1.98］ vs ［20.25 ± 2.82 ］%, P0.01), but also the percentage of grade a sperm (［6.44 ± 1.16］ vs ［13.31 ± 2.30］%, P0.05). Moreover, in comparison with the blank control group, 2 Hz TEAS also remarkably increased sperm motility (［9.57 ± 1.60］ vs ［18.89 ± 2.46］%, P0.05) and the percentage of grade a+b sperm (［7.81 ± 1.31］ vs ［16.32 ± 2.10］%, P0.05) in the asthenozoosperma patients, while 100 Hz TEAS improved not only sperm motility (［9.57 ± 1.60］ vs ［23.81 ± 3.42］%, P0.01) and the percentage of grade a+b sperm (［7.81 ± 1.31］ vs ［20.25 ± 2.82］%, P0.01) but also the percentage of grade a sperm (［4.87 ± 1.01］ vs ［13.31 ± 2.30］%, P0.01). Meanwhile, the rate of clinical effectiveness was significantly higher in the 100 Hz TEASthan in the blank control group either in intention-to-treat (ITT) analysis (100% vs 18.18%) orper-protocol (PP) analysis (90% vs 0%), and so was it than in the 2 Hz TEAS group based on the data of ITT (100% vs 33.33%).Both 2 Hz and 100 Hz TEAS are effective for the treatment of asthenozoospermia by improving sperm motility and vitality.目的： 研究经皮穴位电刺激(TEAS)对弱精子症患者的治疗效果。方法： 将72例弱精子症患者随机分为：2 Hz TEAS治疗组（29例）、100 Hz TEAS治疗组 （20例）及空白对照组（23例）。TEAS治疗组选取双侧肾俞穴、左侧足三里穴及关元穴4个穴位；TEAS参数：施以连续波，频率2 Hz或100 Hz，每日1次，每次30 min 。空白对照组不采取任何治疗手段，时间均为60 d。通过计算机辅助精子分析(CASA)观察2 Hz及100 Hz TEAS治疗对弱精子症患者的精子活动率、浓度、a级精子百分 率及a+b级精子百分率等指标的影响。 同时采用意向治疗分析(ITT)和符合方案数据分析(PP)对临床疗效进行评判。结果： 与治疗前比较，2 Hz TEAS治疗可显著提高 弱精子症患者的精子活动率［(12.76 ± 1.39)% vs (18.89 ± 2.46)%, P0.05］及a+b级精子百分率［(10.68 ± 1.22)% vs （16.32 ± 2.10）%, P0.05］；100 Hz TEAS治疗不仅能够提高弱精子症患者的精子活动率［(12.32 ± 2.21)% vs (23.81± 3.42)%, P0.01］及a+b级精 子百分率［(10.45 ± 1.98)% vs (20.25 ± 2.82)%, P0.01］，而且还能够提高a级精子百分率［(6.44 ± 1.16)% vs (13.31 ± 2.30)%, P0.05］。此外，2 Hz TEAS治疗组的精子活动率［(9.57 ± 1.60)% vs (18.89 ± 2.46)%, P0.05］及a+b级精子百分率［(7.81 ± 1.31)% vs (16.32 ± 2.10)%, P0.05］显著高于空白对照组治疗后；100 Hz TEAS治疗组的精子活动率［(9.57 ± 1.60)% vs (23.81 ± 3.42)%, P0.01］、a+b级精子百分率［(7.81 ± 1.31)% vs (20.25 ± 2.82)%, P0.01］及a级精子百分率［(4.87 ± 1.01)% vs (13.31 ± 2.30)%, P0.01］亦均显著高于空白对照组治疗后。 同时100 Hz TEAS的临床疗效无论是在ITT数据集( 100% vs 18.18%)，还是PP数据集中( 90% vs 0%) 均显著高于空白对照组；而在ITT数据集中，100 Hz TEAS的临床疗效(100% vs 33.33%)亦显著高于2 Hz TEAS。 结论： 2 Hz、100 Hz经皮穴位电刺激均可以提高弱精 子症患者的精子活动率和活力，对弱精子症有一定的治疗作用。. |
