Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice

Autor:	E, Dubnau, J, Chan, C, Raynaud, V P, Mohan, M A, Lanéelle, K, Yu, A, Quémard, I, Smith, M, Daffé
Rok vydání:	2000
Předmět:	Glycerol Cell Membrane Permeability Virulence Hydrogen Peroxide Mycobacterium tuberculosis Chenodeoxycholic Acid Monocytes Cell Line Mice Inbred C57BL Mice Mycolic Acids Genes Bacterial Mutagenesis Animals Humans Tuberculosis Female Oxidation-Reduction
Zdroj:	Molecular microbiology. 36(3)
ISSN:	0950-382X
Popis:	Members of the Mycobacterium tuberculosis group synthesize a family of long-chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non-oxygenated alpha-mycolic acid and the oxygenated keto- and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b39c709fbf84a0b429d99b301f10c300 https://pubmed.ncbi.nlm.nih.gov/10844652 Zobrazit plný text záznamu Plný text