[Influence of genetic mutations on clinical presentation of subretinal neovascularization. Report 1: The impact of CFH and IL-8 genes polymorphism]
| Autor: | M V, Budzinskaia, T V, Pogoda, É V, Generozov, E A, Chikun, I V, Shchegoleva, É É, Kazarian, N S, Galoian |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Aged 80 and over Male Neovascularization Pathologic Choroid Interleukin-8 Subretinal Fluid Retinal Vessels Middle Aged Polymorphism Single Nucleotide Choroidal Neovascularization Radiography Macular Degeneration Complement Inactivating Agents Chorioretinitis Risk Factors Complement Factor H Mutation Myopia Degenerative Humans Female Genetic Predisposition to Disease Fluorescein Angiography Aged |
| Zdroj: | Vestnik oftalmologii. 127(4) |
| ISSN: | 0042-465X |
| Popis: | Genetic analysis was performed in patients with subretinal neovascularization (CNV). The results showed significant association of CFH (compliment factor H) gene polymorphism with increase (rs1061170, rs514943 and rs380390) or decrease (rs529825, rs7524776, rs1831281, rs2274700, rs1576340, rs12144939, rs7540032) of CNV development risk. The incidence of IL-8 gene mutation was significantly (p = 0.008) higher in patients after chorioretinitis. Apparently -125A polymorphism in patients with chorioretinitis increases risk of CNV development, thus promoting raise of proangiogenic factors concentration in eyes with inflammatory background. The clinical presentation in patients with AMD and myopic disease associated with (-125) A mutation of promoter region of IL-8 gene was similar to that of patients with chorioretinitis. The features are the following: focal pattern, no drusen and RPE detachment, predominantly classic form of CNV (without occult pattern), formation of well-organized newly developed vessels. |
| Databáze: | OpenAIRE |
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