| Autor: |
H, Flindt-Hansen, P, Thune, T, Eeg-Larsen |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Acta dermato-venereologica. 70(1) |
| ISSN: |
0001-5555 |
| Popis: |
Photocarcinogenesis was induced in 90 lightly-pigmented hairless mice using a Philips Tl 40 W/12 light source which emits mainly UVB (290-320 nm). During one-third of the induction period (weeks 16-26) a group of 30 mice were protected by topical para-aminobenzoic acid (PABA) and then irradiated again without protection up to week 30 and observed for a further 10 weeks. The application of PABA resulted in a significant delay (p less than 0.05) in tumour induction and discontinuation of PABA caused an abrupt decline in the number of tumour-free animals. At the end of the study there was a significant difference in the yield of carcinomas for the PABA group, 20, compared with 78 for non-protected mice (p less than 0.05). There was also a statistically significant difference (p less than 0.05) between the weight of dorsal skin in non-protected mice compared with the PABA-protected group, the latter showing no difference from a control group of non-irradiated mice. The proportion of benign tumours in the PABA group was significantly (p less than 0.05) higher than in the non-protected group, suggesting an inhibition of the photo-carcinogenic process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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