Time-trends in gastroprotection with nonsteroidal anti-inflammatory drugs (NSAIDs)

Autor: V E, Valkhoff, E M, van Soest, M C J M, Sturkenboom, E J, Kuipers
Rok vydání: 2010
Předmět:
Zdroj: Alimentary pharmacologytherapeutics. 31(11)
ISSN: 1365-2036
Popis: Preventive strategies are advocated in patients at risk of upper-gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs (NSAIDs).To examine time-trends in preventive strategies.In a study population comprising 50 126 NSAID usersor =50 years from the Integrated Primary Care Information database, we considered two preventive strategies: co-prescription of gastroprotective agents and prescription of a cyclooxygenase-2-selective inhibitor. In patients withor =1 risk factor (history of upper-gastrointestinal bleeding/ulceration, age65 years, use of anticoagulants, aspirin, or corticosteroids), correct prescription was defined as the presence of a preventive strategy and under-prescription as the absence of one. In patients with no risk factors, correct prescription was defined as the lack of a preventive strategy, and over-prescription as the presence of one.Correct prescription rose from 6.9% in 1996 to 39.4% in 2006 (P0.01) in high-risk NSAID users. Under-prescription fell from 93.1% to 59.9% (P0.01). In the complete cohort, over-prescription rose from 2.9% to 12.3% (P0.01).Under-prescription of preventive strategies has steadily decreased between 1996 and 2006; however, 60% of NSAID users at increased risk of NSAID complications still do not receive adequate protection.
Databáze: OpenAIRE
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