Modulatory Effect of Taurine on 7,12-Dimethylbenz(a)Anthracene-Induced Alterations in Detoxification Enzyme System, Membrane Bound Enzymes, Glycoprotein Profile and Proliferative Cell Nuclear Antigen in Rat Breast Tissue
| Autor: | Manickam Kalappan, Vanitha, Kuppusamy, Baskaran, Kuppusamy, Periyasamy, Sundaramoorthy, Selvaraj, Aruldoss, Ilakkia, Dhiravidamani, Saravanan, Ramachandran, Venkateswari, Balasundaram, Revathi Mani, Pandi, Anandakumar, Dhanapal, Sakthisekaran |
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| Rok vydání: | 2016 |
| Předmět: |
Taurine
9 10-Dimethyl-1 2-benzanthracene Gene Expression Profiling Mammary Neoplasms Experimental Membrane Transport Proteins Antineoplastic Agents Metabolic Detoxication Phase II Rats Gene Expression Regulation Neoplastic Protein Carbonylation Rats Sprague-Dawley Mammary Glands Animal Proliferating Cell Nuclear Antigen Carcinogens Animals Cytochromes Female Metabolic Detoxication Phase I Glycoproteins |
| Zdroj: | Journal of biochemical and molecular toxicology. 30(8) |
| ISSN: | 1099-0461 |
| Popis: | The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase I drug metabolizing enzymes (cytochrome P450, cytochrome b5, NADPH cytochrome c reductase), phase II drug metabolizing enzymes (glutathione-S-transferase and UDP-glucuronyl transferase), glycoprotein levels, and proliferative cell nuclear antigen (PCNA) were studied. DMBA-induced breast tumor bearing rats showed abnormal alterations in the levels of protein carbonyls, activities of membrane bound enzymes, drug metabolizing enzymes, glycoprotein levels, and PCNA protein expression levels. Taurine treatment (100 mg/kg body weight) appreciably counteracted all the above changes induced by DMBA. Histological examination of breast tissue further supported our biochemical findings. The results of the present study clearly demonstrated the chemotherapeutic effect of taurine in DMBA-induced breast cancer. |
| Databáze: | OpenAIRE |
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