| Autor: |
Marina, Cindric, Ana, Cipak, Julianna, Serly, Aiva, Plotniece, Morana, Jaganjac, Lidija, Mrakovcic, Tomislava, Lovakovic, Azra, Dedic, Ivo, Soldo, Gunars, Duburs, Neven, Zarkovic, József, Molnár |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Anticancer research. 30(10) |
| ISSN: |
1791-7530 |
| Popis: |
Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies.The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance.The effects of amphiphilic dihydropyridine derivative K-2-11 were tested on MDR1-expressing mouse lymphoma cells and their parental control. The effects of K-2-11 with and without doxorubicin were studied by determination of cell viability, cell proliferation and production of reactive oxygen species.K-2-11 caused complete reversal of multidrug resistance of the MDR cells, being much more efficient than the positive control verapamil. Accordingly, the cytotoxic effects of doxorubicin were enhanced by K-2-11, both in the MDR and in parental cell line, while K-2-11 alone did not affect cell viability. K-2-11 also acted as an antioxidant, reducing the cellular generation of reactive oxygen species.Our results indicate the high potential of K-2-11 as a novel antioxidant with potent MDR-blocking ability that should be studied further for development in adjuvant anticancer treatments. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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