| Autor: |
B N, Matiushin, A S, Loginov, V D, Tkachev |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Voprosy meditsinskoi khimii. 43(4) |
| ISSN: |
0042-8809 |
| Popis: |
Repression of cytochrom P-450-dependent hydroxylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione-dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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