[Cytochrome P-450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in chronic liver diseases]

Autor:	B N, Matiushin, A S, Loginov, V D, Tkachev
Rok vydání:	1997
Předmět:	Glutathione Peroxidase Glutathione Reductase Liver Liver Diseases Chronic Disease Microsomes Liver Cytochrome P-450 Enzyme Inhibitors Humans Hydroxylation Glutathione Glutathione Transferase
Zdroj:	Voprosy meditsinskoi khimii. 43(4)
ISSN:	0042-8809
Popis:	Repression of cytochrom P-450-dependent hydroxylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione-dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b2e960dadf543bd59439fe4888b999ae https://pubmed.ncbi.nlm.nih.gov/9312941 Zobrazit plný text záznamu