[Estradiol binding by serum proteins in the postmenopause of women with breast cancer]

Autor:	I T, Nikolov, O A, Dimitrov
Rok vydání:	1990
Předmět:	Radioligand Assay Estradiol Chromatography Gel Humans Breast Neoplasms Female Blood Proteins Receptors Estradiol Menopause Middle Aged Protein Binding
Zdroj:	Problemy endokrinologii. 36(5)
ISSN:	0375-9660
Popis:	It has been established by Scatchard's plots that in breast cancer women the association constant (Ka) and the number of receptor sites (N) at binding of estradiol to serum proteins are changed considerably as compared to those in clinically healthy persons (the control group) Ka is increased and N is diminished. A higher level of free serum estradiol was measured by RIA in breast cancer patients. Serum gel filtration in column showed a decrease in globulin binding and an increase in the level of the albumin-bound labeled ligand as compared to the controls.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b2d17d2a2d9a92ed67f96380a8053bab https://pubmed.ncbi.nlm.nih.gov/2080141 Zobrazit plný text záznamu