| Autor: |
Patra, Vezyraki, Angeliki, Vlachaki, Dimitrios, Baltogiannis, Anna, Batistatou, Stavros, Tsampalas, Yannis, V Simos, Aris, Kaltsas, Periklis, Pappas, Evangelia, Dounousi, Vasilios, Ragos, Evangelos, Tsiambas, Dimitrios, Peschos |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 24(5) |
| ISSN: |
2241-6293 |
| Popis: |
To evaluate the potential of prostate cancer detection on the basis of prostate-specific antigen (PSA)-level and percent free PSA (% fPSA) according to the outcome of prostate needle biopsy.This was a retrospective study of 1040 patients that underwent a prostate biopsy in the Urologic Clinic of the University Hospital of Ioannina, Greece. The patients underwent needle biopsy after abnormal finding in digital rectal examination (DRE). Tissue samples were extracted using a 12-core TRUS-GB. The patients were divided into four groups according to the biopsy outcome. Total serum and free PSA were measured.The mean PSA concentration of cancer versus noncancer groups was significantly higher (p0.05). The positive predictive value (PPV) of PSA for serum concentration10 ng/ml was 47% while the negative predictive value (NPV) in patients with PSA levels4 ng/ml was 81%. The diagnostic accuracy of % fPSA for patients with PSA level between 4-10 ng/ml was 0.651 (95% CI, 0.549-0.754) (p0.05). A statistically significant difference in mean PSA concentration was recorded between prostate cancers classified as grade 2 (3+4=7) and 3 (4+3=7) and grade 4 (8) and 5 (9-10) (p0.05).Though informative and suggestive, PSA and % fPSA are not definitive for cancer or non-cancer determination. The differentiation of PSA level between tumours classified as grade 2 (3+4=7) and grade 3 (4+3=7) could support the determination of treatment by backing pathologist's interpretation of the histological diagnosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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