| Autor: |
Subir, Roy Chowdhury, Jelena, Djordjevic, Ella, Thomson, Darrell R, Smith, Benedict C, Albensi, Paul, Fernyhough |
| Rok vydání: |
2017 |
| Zdroj: |
Molecular and cellular neurosciences. 90 |
| ISSN: |
1095-9327 |
| Popis: |
Abnormalities in mitochondrial function under diabetic conditions can lead to deficits in function of cortical neurons and their support cells exhibiting a pivotal role in the pathogenesis of several neurodegenerative disorders, including Alzheimer's disease. We aimed to assess mitochondrial respiration rates and membrane potential or HCortical mitochondria from streptozotocin (STZ)-induced type 1 diabetic rats or mice, and aged-matched controls were used for simultaneous measurements of mitochondrial respiration rates and mitochondrial membrane potential (mtMP) or HMitochondrial coupled respiration rates and FCCP-induced uncoupled respiration rates were significantly decreased in mitochondria of cortex of STZ-diabetic rats compared to controls. The mtMP in the presence of ADP was significantly depolarized and succinate-dependent respiration rates and HDeficits in mitochondrial function, dynamics, and antioxidant capabilities putatively mediated through sub-optimal AMPK/SIRT/PGC-1α signaling, are involved in the development of early sub-clinical neurodegeneration in the cortex under diabetic conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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