| Autor: |
Naiqi, Niu, Qian, Liu, Xinhua, Hou, Xin, Liu, Ligang, Wang, Fuping, Zhao, Hongmei, Gao, Lijun, Shi, Lixian, Wang, Longchao, Zhang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Animal geneticsREFERENCES. 53(5) |
| ISSN: |
1365-2052 |
| Popis: |
As one of the few animals with variation in the number of rib pairs (RIB), the pig is a good model to study the mechanism of RIB regulation. Quantitative trait loci (QTL) for porcine RIB are present on Sus scrofa chromosome 7 (SSC7). Although several candidate genes exist in this QTL region on SSC7, the causal gene has yet to be verified. Beijing Black pig with 14-17 RIB is a good population for candidate gene mining and 1104 individuals were genotyped using the Illumina Porcine 50K BeadChip. A total of 14 SNPs from 95.49 to 97.78 Mb on SSC7 showed genome-wide significant association with RIB. On SSC7, a locuszoom plot using pairwise linkage disequilibrium displayed the narrowest linkage region encompassing only two genes, ABCD4 and VRTN. In mice, a transcriptome expression profile was obtained using three embryos at E9.5 (the critical period for rib formation). ABCD4 was highly expressed, but no expression of VRTN was detected. On SSC6, there were four genome-wide significant SNPs from 106.42 to 106.92 Mb associated with RIB. GREB1L and MIB1, in this region, were regarded as novel candidate genes. These results revealed a crucial candidate causal gene on SSC7 and novel genes on SSC6 for rib number and provided interesting new insights into its genetic basis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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